Cell membrane and cytoplasmic epidermal growth factor receptor expression in pancreatic ductal adenocarcinoma.

@article{Mahipal2012CellMA,
  title={Cell membrane and cytoplasmic epidermal growth factor receptor expression in pancreatic ductal adenocarcinoma.},
  author={Amit Mahipal and Mary J Mcdonald and Agnieszka W Witkiewicz and Brian I Carr},
  journal={Medical oncology},
  year={2012},
  volume={29 1},
  pages={134-9}
}
The significance of over-expression of epidermal growth factor receptor (EGFR) in pancreatic carcinoma is unclear. In this study, we examined the association between EGFR over-expression (membranous and cytoplasmic), the associated histopathologic features and clinical outcomes in post-resection pancreatic cancer patients. EGFR expression was determined immunohistochemically in 90 patients who underwent resection for pancreatic cancer. Cytoplasmic expression was considered positive if EGFR… CONTINUE READING

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