Cell-mediated transfer of catalase nanoparticles from macrophages to brain endothelial, glial and neuronal cells.

@article{Haney2011CellmediatedTO,
  title={Cell-mediated transfer of catalase nanoparticles from macrophages to brain endothelial, glial and neuronal cells.},
  author={Matthew J. Haney and Yuling Zhao and Shu Li and Sheila M Higginbotham and Stephanie L Booth and Huai-Yun Han and Joseph A. Vetro and R. Lee Mosley and Alexander V. Kabanov and Howard E. Gendelman and Elena V. Batrakova},
  journal={Nanomedicine},
  year={2011},
  volume={6 7},
  pages={
          1215-30
        }
}
BACKGROUND Our laboratories forged the concept of macrophage delivery of protein antioxidants to attenuate neuroinflammation and nigrostriatal neurodegeneration in Parkinson's disease. Notably, the delivery of the redox enzyme, catalase, incorporated into a polyion complex micelle ('nanozyme') by bone marrow-derived macrophages protected nigrostriatum against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication. Nonetheless, how macrophage delivery of nanozyme increases the efficacy of… 
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This study developed a nanoformulation of cinnamic aldehyde, termed Antioxidant Response Activating nanoParticles (ARAPas), that can be readily loaded into macrophages ex vivo and highlights the feasibility of CA encapsulation and subsequent macrophage uptake for delivery of cargo into other pertinent cells, such as VSMC.
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The results provided great potential of macrophages as an active biocarrier to deliver anticancer drugs to the tumor sites in the brain and improve therapeutic effects of glioma.
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