Cell-mediated suppression of human hematopoiesis: evaluation by limiting-dilution analysis of hematopoietic progenitors.

@article{Takaue1989CellmediatedSO,
  title={Cell-mediated suppression of human hematopoiesis: evaluation by limiting-dilution analysis of hematopoietic progenitors.},
  author={Yoichi Takaue and Christopher L. Reading and Takeshi Watanabe and Yutaka Kawano and Takashi Ninomiya and Y Iishi and Mitsuko Kosaka and Eiko Shimizu and Takao Ichioka and Toru Hosoda},
  journal={American journal of hematology},
  year={1989},
  volume={32 3},
  pages={205-11}
}
We have used limiting-dilution clonal analysis (LDA) in microwells to study the inhibitory effects of T lymphocytes (T-cells) or natural killer (NK) cells on human marrow progenitor cell growth. In four subjects with normal hematopoiesis, the growth of progenitors showed single-hit kinetics both before and after T-cell removal, indicating that, in the… CONTINUE READING