Cell-mediated immunity to herpes simplex virus: specificity of cytotoxic T cells.

@article{Lawman1980CellmediatedIT,
  title={Cell-mediated immunity to herpes simplex virus: specificity of cytotoxic T cells.},
  author={Michael J. P. Lawman and Richard J. Courtney and Rebekka Eberle and Priscilla A. Schaffer and M K O'Hara and Barry T Rouse},
  journal={Infection and immunity},
  year={1980},
  volume={30 2},
  pages={451-61}
}
This communication deals with the question of which of the viral antigens constitutes the targets for cytotoxic T lymphocytes (CTL) generated against herpes simplex virus type 1 (HSV-1). The approach used was, first, to compare cytotoxicity of CTL against target cells infected with virus in the presence of tunicamycin and 2-deoxy-D-glucose, which are known to inhibit glycoprotein synthesis, and second, to compare cytotoxicity of CTL against target cells infected with wild-type HSV-1 with that… CONTINUE READING
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Preparation and characterization of specific antisera to individual glycoprotein antigens comprising the major glycoprotein region of herpes simplex virus type 1

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Trype - common CP - 1 antigen of herpes simplex virus is associated with a 59 , 000 - molecular - weight envelope glycoprotein

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