Cell-mediated immunity to chemically xenogenized tumors. II. Evidence for accessory function and self-antigen presentation by a highly immunogenic tumor variant.

@article{Romani1988CellmediatedIT,
  title={Cell-mediated immunity to chemically xenogenized tumors. II. Evidence for accessory function and self-antigen presentation by a highly immunogenic tumor variant.},
  author={Luigina Romani and Ursula Grohmann and Paolo Puccetti and Bernardetta Nardelli and Michael G. Mage and Maria Cristina Fioretti},
  journal={Cellular immunology},
  year={1988},
  volume={111 2},
  pages={
          365-78
        }
}
To determine whether antigen-presenting ability might be involved in the superior immunogenicity of chemically xenogenized tumors over that of parental cells, we tested a murine lymphoma line xenogenized by a triazene derivative for expression of Ia antigens, ability to present soluble antigen in vitro, and production of factor(s) active in a mouse thymocyte assay. Results showed that Ia antigens, absent on nonimmunogenic parental L5178Y cells, were expressed on a xenogenized, highly… CONTINUE READING