Cell-mediated immunity to Toxoplasma gondii develops primarily by local Th1 host immune responses in the absence of parasite replication.

Abstract

A single inoculation of mice with the live, attenuated Toxoplasma gondii uracil auxotroph strain cps1-1 induces long-lasting immunity against lethal challenge with hypervirulent strain RH. The mechanism for this robust immunity in the absence of parasite replication has not been addressed. The mechanism of long-lasting immunity, the importance of route of… (More)

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@article{Gigley2009CellmediatedIT, title={Cell-mediated immunity to Toxoplasma gondii develops primarily by local Th1 host immune responses in the absence of parasite replication.}, author={Jason P. Gigley and Barbara A. Fox and David J Bzik}, journal={Journal of immunology}, year={2009}, volume={182 2}, pages={1069-78} }