Cell-mediated immunity to Bordetella pertussis: role of Th1 cells in bacterial clearance in a murine respiratory infection model.

@article{Mills1993CellmediatedIT,
  title={Cell-mediated immunity to Bordetella pertussis: role of Th1 cells in bacterial clearance in a murine respiratory infection model.},
  author={Kingston H G Mills and Ann C. Barnard and J Watkins and Keith Redhead},
  journal={Infection and immunity},
  year={1993},
  volume={61 2},
  pages={399-410}
}
A murine respiratory infection model was used to study the mechanism of protective immunity to Bordetella pertussis. We found that nude mice, which are deficient in T cells, developed a persistent infection and failed to clear the bacteria after aerosol inoculation. In contrast, normal adult nonimmune mice cleared a respiratory infection approximately 35 days after challenge. Before bacterial clearance, antipertussis antibody levels in serum were low or undetectable, whereas consistent antigen… CONTINUE READING

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