Cell-mediated and humoral immune responses after vaccination of human volunteers with the live vaccine strain of Francisella tularensis.

@article{Waag1995CellmediatedAH,
  title={Cell-mediated and humoral immune responses after vaccination of human volunteers with the live vaccine strain of Francisella tularensis.},
  author={David M. Waag and Kelly T. McKee and G Sandstrom and Linda Pratt and Chris R Bolt and Marilyn J England and Gene O Nelson and Julian C. Williams},
  journal={Clinical and diagnostic laboratory immunology},
  year={1995},
  volume={2 2},
  pages={143-8}
}
The specific humoral and cell-mediated immune responses of human volunteers vaccinated with the Francisella tularensis live vaccine strain (LVS) were evaluated. In the search for an optimal antigen to measure the immunogenicity of the vaccine in an enzyme-linked immunosorbent assay, we tested irradiation-killed LVS, an aqueous ether extract of the LVS (EEx), lipopolysaccharide (LPS) from LVS, and a virulent strain (SCHU4). Volunteers were immunized with LVS by scarification. Immunoglobulin G… CONTINUE READING