Cell mechanics control rapid transitions between blebs and lamellipodia during migration.

@article{Bergert2012CellMC,
  title={Cell mechanics control rapid transitions between blebs and lamellipodia during migration.},
  author={Martin Bergert and Stanley D. Chandradoss and Ravi A. Desai and Ewa K Paluch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 36},
  pages={14434-9}
}
Protrusion formation is an essential step during cell migration. Cells migrating in three-dimensional environments and in vivo can form a wide variety of protrusion types, including actin polymerization-driven lamellipodia, and contractility-driven blebs. The ability to switch between different protrusions has been proposed to facilitate motility in complex environments and to promote cancer dissemination. However, plasticity in protrusion formation has so far mostly been investigated in the… CONTINUE READING
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