Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing.

@article{SaarialhoKere1993CellmatrixIM,
  title={Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing.},
  author={Ulpu K Saarialho-Kere and Stephen O Kovacs and Alice P. Pentland and John E. Olerud and Howard G. Welgus and William C. Parks},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={92 6},
  pages={2858-66}
}
We reported that interstitial collagenase is produced by keratinocytes at the edge of ulcers in pyogenic granuloma, and in this report, we assessed if production of this metalloproteinase is a common feature of the epidermal response in a variety of wounds. In all samples of chronic ulcers, regardless of etiology, and in incision wounds, collagenase mRNA, localized by in situ hybridization, was prominently expressed by basal keratinocytes bordering the sites of active re-epithelialization… CONTINUE READING

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