Cell-matrix interactions during development and apoptosis of the mouse mammary gland in vivo.

@article{Prince2002CellmatrixID,
  title={Cell-matrix interactions during development and apoptosis of the mouse mammary gland in vivo.},
  author={Janine M Prince and Teresa C M Klinowska and Emma Marshman and Emma T. Lowe and Ulrike Mayer and Jeff Miner and Daniel Aberdam and Dietmar Vestweber and Barry Gusterson and Charles H Streuli},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2002},
  volume={223 4},
  pages={497-516}
}
Epithelial cell survival is dependent on extracellular signals provided by both soluble factors and by adhesion. In the mammary gland, extensive apoptosis of epithelial cells occurs rapidly when lactation ceases, but the mechanism of apoptosis induction is not known. In tissue culture, mammary epithelial cells require laminin as a survival ligand and specific beta1 integrins are necessary to suppress apoptosis. To explore the possibility that dynamic changes in cell-matrix interactions… CONTINUE READING

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