Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration.

  title={Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration.},
  author={Cari Dorey and Gloria Wu and D B Ebenstein and Armando Garsd and John J. Weiter},
  journal={Investigative ophthalmology & visual science},
  volume={30 8},
We examined the impact of aging on the numbers of photoreceptors and retinal pigment epithelium (RPE) cells, and the number of photoreceptors per RPE cell profile, in selected regions of 30 human eyes. The mean ratio of photoreceptors to RPE cell was higher in the macula than in the paramacula (P less than 0.01) or the equatorial area (P less than 0.001). We found evidence for an age-related loss of RPE in both whites (P less than 0.02) and blacks (P less than 0.0006), although the rate of loss… CONTINUE READING
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