Cell loss and recovery in umbilical cord blood processing: a comparison of postthaw and postwash samples.

@article{Laroche2005CellLA,
  title={Cell loss and recovery in umbilical cord blood processing: a comparison of postthaw and postwash samples.},
  author={Vincent Laroche and David H. McKenna and Gary Moroff and Therese Schierman and Diane M Kadidlo and Jeffrey McCullough},
  journal={Transfusion},
  year={2005},
  volume={45 12},
  pages={1909-16}
}
BACKGROUND Engraftment after umbilical cord blood (UCB) transplantation is highly dependent on nucleated cell (NC) and CD34+ cell content. Current standard postthaw (PT) processing includes a wash step to remove dimethyl sulfoxide (DMSO), lysed red cells, and stroma. The contribution of the wash step to cell loss and ultimately the dose of cells available for transplant have yet to be systematically reported. This study examines the effect of the wash step as well as that of PT storage on… CONTINUE READING

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