Cell lines of pulmonary and non-pulmonary origin as tools to study the effects of house dust mite proteinases on the regulation of epithelial permeability.

@article{Winton1998CellLO,
  title={Cell lines of pulmonary and non-pulmonary origin as tools to study the effects of house dust mite proteinases on the regulation of epithelial permeability.},
  author={Helen L. Winton and Huajing Wan and Mark B. Cannell and Dieter C. Gruenert and Phillip J. Thompson and David Ronald Garrod and Geoffrey A. Stewart and Ch.T. Robinson},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={1998},
  volume={28 10},
  pages={
          1273-85
        }
}
BACKGROUND Allergenic and non-allergenic proteinases from house dust mites (HDM) cause loss of adhesion between airway epithelial cells that may result in a loss of functional cohesion between the cells and thus assist in allergen presentation. Improved cellular assay systems are needed to ascertain the mechanisms involved. OBJECTIVES To survey a series of epithelial cell lines (Calu-3, 16HBE14o-, NCI-H292 and A549 from human airways, and MDCK from dog kidney) and establish their utility for… CONTINUE READING
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