Cell lines from grc congenic strains of rats having different susceptibilities to chemical carcinogens.

@article{Lu1993CellLF,
  title={Cell lines from grc congenic strains of rats having different susceptibilities to chemical carcinogens.},
  author={Dan Lu and Heinz W. Kunz and Mona F. Melhem and Thomas J. Gill},
  journal={Cancer research},
  year={1993},
  volume={53 17},
  pages={4089-95}
}
The growth and reproduction complex (grc-) strains of rats have a 70-kilobase deletion in the major histocompatibility complex (MHC)-linked grc-G/C region that is associated with embryonic death, developmental defects, and an increased susceptibility to chemical carcinogens. To study further the effects associated with the deletion, fibroblastic cell lines from grc-, grc+, and grc+/- rat embryos were developed: BIL-derived cell lines are congenic for the MHC and grc, whereas R16-derived cell… CONTINUE READING

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