Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma.

@article{Cheng2007CellLF,
  title={Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma.},
  author={Andy J Cheng and Ngan Ching Cheng and Jette Ford and Janice C. Smith and Jayne Murray and Claudia L. Flemming and Maria Lastowska and Michael S. Jackson and Christopher Hackett and William S. Weiss and Glenn M. Marshall and Ursula R. Kees and Murray D. Norris and Michelle Haber},
  journal={European journal of cancer},
  year={2007},
  volume={43 9},
  pages={1467-75}
}
Overexpression of the human MYCN oncogene driven by a tyrosine hydroxylase promoter causes tumours in transgenic mice that recapitulate the childhood cancer neuroblastoma. To establish an in vitro model to study this process, a series of isogenic cell lines were developed from these MYCN-driven murine tumours. Lines were established from tumours arising in homozygous and hemizygous MYCN transgenic mice. Hemizygous tumours gave rise to cell lines growing only in suspension. Homozygous tumours… CONTINUE READING

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