Cell lineage and patterns of migration in the developing cortex.

  title={Cell lineage and patterns of migration in the developing cortex.},
  author={Christopher T Walsh and Catriona B. Reid},
  journal={Ciba Foundation symposium},
  pages={21-40; discussion 59-70}
Knowledge of cell lineage in the cortex is important for understanding normal development as well as brain malformations. We studied cell lineage in rats by injecting a library of up to 3400 retroviruses, distinguishable by PCR analysis and encoding alkaline phosphatase, at E14-19. Histological analysis at P15 revealed normal cell morphology and allowed identification of about 80% of all labelled cells. PCR amplification of DNA tags allowed clonal analysis. Cortical cells labelled at E15 formed… CONTINUE READING

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