Cell-layer-associated proteolytic cleavage of the telopeptides of type I collagen in fibroblast culture.

@article{Bateman1987CelllayerassociatedPC,
  title={Cell-layer-associated proteolytic cleavage of the telopeptides of type I collagen in fibroblast culture.},
  author={John F Bateman and Jane J. Pillow and Tom Mascara and S Medvedec and John A. M. Ramshaw and William G. Cole},
  journal={The Biochemical journal},
  year={1987},
  volume={245 3},
  pages={677-82}
}
In human skin fibroblast cultures a fraction of the procollagen that was processed to collagen and remained in the cell layer was further proteolytically modified by removal of both N- and C-terminal telopeptides. The proteolytic activity was associated with the cell layer, since secreted collagens were found always to contain intact telopeptides. The inclusion of neutral polymers, which caused the accumulation of the collagen in the cell layer [Bateman, Cole, Pillow & Ramshaw (1986) J. Biol… CONTINUE READING

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