Cell kinetics of mouse urinary bladder epithelium. II. Changes in proliferation and nuclear DNA content during necrosis regeneration, and hyperplasia caused by a single dose of cyclophosphamide.

@article{Farsund1976CellKO,
  title={Cell kinetics of mouse urinary bladder epithelium. II. Changes in proliferation and nuclear DNA content during necrosis regeneration, and hyperplasia caused by a single dose of cyclophosphamide.},
  author={T Farsund},
  journal={Virchows Archiv. B, Cell pathology},
  year={1976},
  volume={21 4},
  pages={279-98}
}
  • T Farsund
  • Published 1976 in Virchows Archiv. B, Cell pathology
The effects of cyclophosphamide (CPA) on the mouse (hr/hr strain) urinary bladder epithelium are described with regard to histology, proliferation (mitotic activity, LI, and cell number), and changes in ploidy. An initial toxic effect on the epithelium was evident after injection of CPA, demonstrated by a focal cell loss of approximately 50% during the period from 10 to 24 h after the injection of CPA. The toxicity is partly direct and partly mediated through DNA replication, and leads to cell… CONTINUE READING
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