Cell kinetic studies in mixed leukocyte cultures: an in vitro model of homograft reactivity.

@article{Bach1969CellKS,
  title={Cell kinetic studies in mixed leukocyte cultures: an in vitro model of homograft reactivity.},
  author={Fritz Heintz Bach and H. -J. Bock and K C Graupner and Edward Day and H Klostermann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1969},
  volume={62 2},
  pages={
          377-84
        }
}
The recognition phase of homograft immunity can be studied in vitro in the mixed leukocyte culture reaction. In this reaction, at the end of seven days, up to 30 per cent of the lymphocytes in culture "respond" to a single allogeneic cell stimulus. This paper presents evidence that the lymphocytes responding in culture divide with the generation time of 18-21 hours, with some asynchrony, and that a large percentage of the cells found at the end of the culture period may be the products by… CONTINUE READING
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