Cell itinerary and metabolic fate of proinsulin in rat liver: in vivo and in vitro studies.

@article{Desbuquois2003CellIA,
  title={Cell itinerary and metabolic fate of proinsulin in rat liver: in vivo and in vitro studies.},
  author={Bernard Desbuquois and Genevi{\`e}ve Chauvet and Mostafa Kouach and François J{\'e}r{\^o}me Authier},
  journal={Endocrinology},
  year={2003},
  volume={144 12},
  pages={5308-21}
}
Proinsulin, the insulin precursor in pancreatic beta-cells, displays a slower hepatic clearance than insulin and exerts a more prolonged metabolic effect on liver in vivo. To elucidate the mechanisms underlying these differences, the cellular itinerary and processing of proinsulin and insulin in rat liver have been comparatively studied using cell fractionation. As [125I]-insulin, [125I]-proinsulin taken up into liver in vivo was internalized and accumulated in endosomes, in which it underwent… CONTINUE READING

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