Cell invasion by Trypanosoma cruzi amastigotes of distinct infectivities: studies on signaling pathways

@article{Fernandes2006CellIB,
  title={Cell invasion by Trypanosoma cruzi amastigotes of distinct infectivities: studies on signaling pathways},
  author={Adriana Barrinha Fernandes and Ivan Neira and Alice Teixeira Ferreira and Renato Arruda Mortara},
  journal={Parasitology Research},
  year={2006},
  volume={100},
  pages={59-68}
}
Trypanosoma cruzi metacyclic trypomastigotes of the major phylogenetic lineages use specific signaling pathways to invade host cells. Using a panel of drugs, we studied if the differences in the ability of extracellular amastigotes (EA) from G (T. cruzi I) and CL (T. cruzi II) strains to invade host cells could be associated to activation of specific signaling routes. Sonicated extracts from G or CL strain EA induced transient raises in HeLa cell intracellular Ca2+ levels in a dose-dependent… CONTINUE READING

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