Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

@article{Ablasser2013CellII,
  title={Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP},
  author={Andrea Ablasser and Jonathan Leo Schmid-Burgk and Inga Hemmerling and Gabor L Horvath and Tobias Schmidt and Eicke Latz and V. Hornung},
  journal={Nature},
  year={2013},
  volume={503},
  pages={530-534}
}
The innate immune defence of multicellular organisms against microbial pathogens requires cellular collaboration. Information exchange allowing immune cells to collaborate is generally attributed to soluble protein factors secreted by pathogen-sensing cells. Cytokines, such as type I interferons (IFNs), serve to alert non-infected cells to the possibility of pathogen challenge. Moreover, in conjunction with chemokines they can instruct specialized immune cells to contain and eradicate microbial… CONTINUE READING

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In line with the limited cargo specificity of connexins , the proteins that assemble gap junction channels , most connexins tested were able to confer this bystander immunity , thus indicating a broad physiological relevance of this local immune collaboration .
In line with the limited cargo specificity of connexins , the proteins that assemble gap junction channels , most connexins tested were able to confer this bystander immunity , thus indicating a broad physiological relevance of this local immune collaboration .
In line with the limited cargo specificity of connexins , the proteins that assemble gap junction channels , most connexins tested were able to confer this bystander immunity , thus indicating a broad physiological relevance of this local immune collaboration .
In line with the limited cargo specificity of connexins , the proteins that assemble gap junction channels , most connexins tested were able to confer this bystander immunity , thus indicating a broad physiological relevance of this local immune collaboration .
In line with the limited cargo specificity of connexins , the proteins that assemble gap junction channels , most connexins tested were able to confer this bystander immunity , thus indicating a broad physiological relevance of this local immune collaboration .
In line with the limited cargo specificity of connexins , the proteins that assemble gap junction channels , most connexins tested were able to confer this bystander immunity , thus indicating a broad physiological relevance of this local immune collaboration .
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