Cell guidance by ultrafine topography in vitro.

  title={Cell guidance by ultrafine topography in vitro.},
  author={Peter Clark and Patricia Connolly and Adam S. G. Curtis and Julian A. T. Dow and Chris D. W. Wilkinson},
  journal={Journal of cell science},
  volume={99 ( Pt 1)},
Laser holography and microelectronic fabrication techniques have been employed to make grating surfaces in fused quartz with ultrafine period (260 nm) in an attempt to mimic the topography of aligned fibrillar extracellular matrix (ECM), which, in the past, has been shown to affect the behaviour of cells in vitro and in vivo. The alignment of BHK cells, MDCK cells and chick embryo cerebral neurones on 260 nm period grating surfaces (130 nm grooves separated by 130 nm) of various depths (100… CONTINUE READING

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