Cell growth- and P53-dependent transcriptional activity of the midkine promoter confers suicide gene expression in tumor cells.

@article{Yu2003CellGA,
  title={Cell growth- and P53-dependent transcriptional activity of the midkine promoter confers suicide gene expression in tumor cells.},
  author={Ling Yu and Shin-ichi Ugai and Jiyang O-Wang and Masayoshi Namba and Kenji Kadomatsu and Takashi Muramatsu and Shuichiro Matsubara and Shigeru Sakiyama and Masatoshi Tagawa},
  journal={Oncology reports},
  year={2003},
  volume={10 5},
  pages={1301-5}
}
Midkine (MK) is preferentially expressed in a number of human tumors, while the expression in adult normal tissues is restricted. Previous studies showed that a 2.3-kb regulatory region of the human MK gene could selectively activate a linked suicide gene in tumors. In this study, we explored the minimal promoter region using genomic fragments deleted from the 5'-upstream side and analyzed the mechanism of the preferential activation in tumor cells. Luciferase assays showed that the 0.3-kb… CONTINUE READING