Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease

@article{Reiter2002CellfreeHL,
  title={Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease},
  author={C. Reiter and X. Wang and J. Tanus-Santos and N. Hogg and R. Cannon and A. Schechter and M. Gladwin},
  journal={Nature Medicine},
  year={2002},
  volume={8},
  pages={1383-1389}
}
Although the deleterious vasoconstrictive effects of cell-free, hemoglobin-based blood substitutes have been appreciated, the systemic effects of chronic hemolysis on nitric oxide bioavailability have not been considered or quantified. Central to this investigation is the understanding that nitric oxide reacts at least 1,000 times more rapidly with free hemoglobin solutions than with erythrocytes. We hypothesized that decompartmentalization of hemoglobin into plasma would divert nitric oxide… Expand
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