Cell-free granulocyte colony inhibiting activity derived from human polymorphonuclear neutrophils.

@article{Broxmeyer1977CellfreeGC,
  title={Cell-free granulocyte colony inhibiting activity derived from human polymorphonuclear neutrophils.},
  author={Hal E. Broxmeyer and Malcolm A. S. Moore and Peter Ralph},
  journal={Experimental hematology},
  year={1977},
  volume={5 2},
  pages={87-102}
}
Human PMN (non-adherent: density greater than 1.070 g/cm3) were used to prepare cell-free colony inhibiting activity (CIA). Intact PMN, PMN conditioned media (serum-free or serum-containing) and supernatant from immediately lysed PMN equally reduced the numbers of spontaneous bone marrow (density less than 1.070 g/cm3; depleted of PMN) colonies and clusters. Addition of CIA reproducibly reduced colony and/or cluster numbers by 35-70%. CIA was heat labile being inactivated at 37 degrees C. Daily… CONTINUE READING

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