Cell for Gonadal and Nongonadal Pediatric Germ Cell Tumors Multipoint Imprinting Analysis Indicates a Common Precursor


Pediatric germ cell tumors (GCTs) commonly arise at extragonadal sites. It has been proposed that nongonadal GCTs arise from ectopic primordial germ cells that have aberrantly migrated during embryogenesis. During a time between their migration and development to mature gametes, primordial germ cells are characterized by their lack of imprinting, which can… (More)


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