Cell fate decisions are specified by the dynamic ERK interactome

  title={Cell fate decisions are specified by the dynamic ERK interactome},
  author={Alex von Kriegsheim and Daniela Baiocchi and Marc Birtwistle and David Sumpton and Willy Bienvenut and Nicholas Morrice and Kayo Yamada and Angus Lamond and Gabriella Kalna and Richard Orton and David W. Gilbert and Walter Kolch},
  journal={Nature Cell Biology},
Extracellular signal-regulated kinase (ERK) controls fundamental cellular functions, including cell fate decisions. In PC12, cells shifting ERK activation from transient to sustained induces neuronal differentiation. As ERK associates with both regulators and effectors, we hypothesized that the mechanisms underlying the switch could be revealed by assessing the dynamic changes in ERK-interacting proteins that specifically occur under differentiation conditions. Using quantitative proteomics, we… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
117 Citations
30 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 117 extracted citations


Publications referenced by this paper.
Showing 1-10 of 30 references

transient versus sustained extracellular signal-regulated kinase activation

  • Marshall, C. J. Specificity of receptor tyrosine kinase signaling
  • Cell 80, 179–185
  • 1995
Highly Influential
8 Excerpts

from signaling specificity to diverse functions

  • Y. D. Shaul, Seger, R. The MEKERK cascade
  • Biochim. Biophys. Acta 1773, 1213–1226
  • 2007

function, regulation and role in human cancer

  • Leicht, D. T. et al. Raf kinases
  • Biochim. Biophys. Acta 1773, 1196–1212
  • 2007
2 Excerpts

Similar Papers

Loading similar papers…