Cell fate decisions are specified by the dynamic ERK interactome

@article{Kriegsheim2009CellFD,
  title={Cell fate decisions are specified by the dynamic ERK interactome},
  author={Alex von Kriegsheim and Daniela Baiocchi and Marc Birtwistle and David Sumpton and Willy Bienvenut and Nicholas Morrice and Kayo Yamada and Angus Lamond and Gabriella Kalna and Richard Orton and David W. Gilbert and Walter Kolch},
  journal={Nature Cell Biology},
  year={2009},
  volume={11},
  pages={1458-1464}
}
Extracellular signal-regulated kinase (ERK) controls fundamental cellular functions, including cell fate decisions. In PC12, cells shifting ERK activation from transient to sustained induces neuronal differentiation. As ERK associates with both regulators and effectors, we hypothesized that the mechanisms underlying the switch could be revealed by assessing the dynamic changes in ERK-interacting proteins that specifically occur under differentiation conditions. Using quantitative proteomics, we… CONTINUE READING

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