Cell fate decision: T-helper 1 and 2 subsets in immune responses


After activation CD4(+) helper T cells differentiate into T-helper (Th) 1 or Th2 effector cells. These two subsets are characterized by their distinct cytokine expression pattern and the immune function they mediate. Over the past years, a number of factors have been identified to affect helper T cell lineage determination, including antigen receptor, coreceptors and, most importantly, cytokine environment. In this review, we also summarize recent advancement in understanding of transcriptional and signaling regulation of the differentiation process. This knowledge will become important in the future to develop means in treating immune disorders.

Extracted Key Phrases

1 Figure or Table


Citations per Year

286 Citations

Semantic Scholar estimates that this publication has 286 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Dong2000CellFD, title={Cell fate decision: T-helper 1 and 2 subsets in immune responses}, author={Chen Dong and Richard A. Flavell}, journal={Arthritis Research}, year={2000}, volume={2}, pages={179 - 188} }