Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines

@article{Kondo2000CellfateCO,
  title={Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines},
  author={Motonari Kondo and David C. Scherer and Toshihiro Miyamoto and Angela G. King and Koichi Akashi and Kazuo Sugamura and Irving L Weissman},
  journal={Nature},
  year={2000},
  volume={407},
  pages={383-386}
}
The primary role of cytokines in haemato-lymphopoiesis is thought to be the regulation of cell growth and survival. But the instructive action of cytokines in haematopoiesis has not been well addressed. Here we show that a clonogenic common lymphoid progenitor, a bone marrow-resident cell that gives rise exclusively to lymphocytes (T, B and natural killer cells), can be redirected to the myeloid lineage by stimulation through exogenously expressed interleukin (IL)-2 and GM-CSF (granulocyte… CONTINUE READING
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