Cell fate commitment during mammalian sex determination.

@article{Lin2015CellFC,
  title={Cell fate commitment during mammalian sex determination.},
  author={Yi-Tzu Lin and Blanche Capel},
  journal={Current opinion in genetics & development},
  year={2015},
  volume={32},
  pages={
          144-52
        }
}
The gonads form bilaterally as bipotential organs that can develop as testes or ovaries. All secondary sex characteristics that we associate with 'maleness' or 'femaleness' depend on whether testes or ovaries form. The fate of the gonads depends on a cell fate decision that occurs in a somatic cell referred to as the 'supporting cell lineage'. Once supporting cell progenitors commit to Sertoli (male) or granulosa (female) fate, they propagate this decision to the other cells within the organ… CONTINUE READING

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