Cell-extracellular matrix interactions and EGF are important regulators of the basal mammary epithelial cell phenotype.

@article{Deugnier1999CellextracellularMI,
  title={Cell-extracellular matrix interactions and EGF are important regulators of the basal mammary epithelial cell phenotype.},
  author={Marie-Ange Deugnier and Marisa M. Faraldo and Patricia Rousselle and Jean Paul Thiery and Marina A. Glukhova},
  journal={Journal of cell science},
  year={1999},
  volume={112 ( Pt 7)},
  pages={1035-44}
}
The mammary epithelium is composed of a luminal epithelium and a basal layer containing myoepithelial cells and undifferentiated precursors. Basal cells express specific protein markers, such as keratin 14 (K14) and P-cadherin. To study the factors that regulate the basal mammary epithelial cell phenotype, we have established two clonal derivatives of the mouse HC11 cell line, BC20 and BC44, expressing high levels of K14 and P-cadherin. Unlike the parental HC11 cells, these basal cells did not… CONTINUE READING

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Stably transfected HC11 cells provide an in vitro and in vivo model system for studying Wnt gene function.

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