Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation.

@article{Gett1998CellDR,
  title={Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation.},
  author={Amanda V. Gett and Philip D. Hodgkin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 16},
  pages={
          9488-93
        }
}
Naive T lymphocytes have the potential to differentiate and produce a range of cytokines crucial for appropriate immune responses. How T lymphocytes vary their cytokine output during differentiation is unknown, although they are clearly influenced by the cytokines already present in the environment. Here we show that the number of divisions taken by the cells after activation is a critical element in T cell differentiation. Our experiments used the dye 5-(and 6-)carboxyfluorescein diacetate… CONTINUE READING

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Gett and Hodgkin Proc

  • Sanderson, 79 C.J.Blood, 3101–3109. Immunology
  • Natl. Acad. Sci. USA 95
  • 1998
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