Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness

@inproceedings{Erbayraktar2016CellDC,
  title={Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness},
  author={Zubeyde Erbayraktar and Begum Alural and Resat Serhat Erbayraktar and Erdogan Pekcan Erkan},
  booktitle={Cancer Cell International},
  year={2016}
}
Genomic instability is a hallmark of cancer cells, and this cellular phenomenon can emerge as a result of replicative stress. It is possible to take advantage of replicative stress, and enhance it in a targeted way to fight cancer cells. One of such strategies involves targeting the cell division cycle 7-related protein kinase (CDC7), a protein with key roles in regulation of initiation of DNA replication. CDC7 overexpression is present in different cancers, and small molecule inhibitors of the… CONTINUE READING

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