Cell division: The renaissance of the centriole

@article{Marshall1999CellDT,
  title={Cell division: The renaissance of the centriole},
  author={Wallace F. Marshall and Joel L. Rosenbaum},
  journal={Current Biology},
  year={1999},
  volume={9},
  pages={R218-R220}
}
Centrioles are located at the center of the cytoskeleton and duplicate exactly once per cell cycle. Recent studies suggest that centrioles are required for the organization of a functional centrosome and that centriole assembly requires both gamma- and delta-tubulin. 
Cytoplasmic Dynein-mediated Assembly of Pericentrin and γ Tubulin onto Centrosomes
TLDR
It is shown that in somatic cells centrosome assembly of two protea is disturbed and if defective may contribute to genomic instability in cancer. Expand
Construction of Centrosomes and Spindle Poles by Molecular Motor‐Driven Assembly of Protein Particles
TLDR
Recent evidence suggesting that assembly of centrosomes and mitotic spindle poles require transport of large protein particles along microtubules by the molecular motor cytoplasmic dynein is summarized. Expand
Requirement of a Centrosomal Activity for Cell Cycle Progression Through G1 into S Phase
TLDR
The observations reveal the existence of an activity associated with core centrosomal structures—distinct from elements of the microtubule-organizing center—that is required for the somatic cell cycle to progress through G1 into S phase, and that these core structures are not needed for the G2-M phase transition. Expand
GFP‐centrin as a marker for centriole dynamics in living cells
TLDR
The introduction of GFP‐centrin into cultured cells allows direct visualization of centriole behavior in living cells and in real time, and demonstrates that the biogenesis of new centrioles from individual members of a preexisting centRIole pair is asynchronous. Expand
The centrosome and parthenogenesis.
TLDR
The most direct experimental approach to search for the essential centriole-associated precursor for centrioles assembly is the parthenogenetic assay in the Xenopus system. Expand
Centriole duplication and maturation in animal cells.
TLDR
The functional role and structural features of the centriole and the molecular events underlying centriolar duplication and maturation are discussed in the chapter and some of the possible future developments in the study of centriol cell biology are described. Expand
Mitotic kinase cascades orchestrating timely disjunction and movement of centrosomes maintain chromosomal stability and prevent cancer
TLDR
Mechanisms that regulate centrosomes dynamics are reviewed, with emphasis on the roles of key mitotic kinases in the proper timing of centrosome dynamics and how aberrancies in these processes may cause chromosomal instability and cancer. Expand
Distribution of tyrosinated and acetylated tubulin in centrioles during mitosis of 3T3 and SV40-3T3 cells
TLDR
It was shown that the pattern of centriole immunostaining changed during the cell cycle in 3T3 (A31) cells, but not in tumorigenic SV40-3T3 cells. Expand
Centriolar satellites: molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis.
TLDR
It is suggested that 100riolar satellites and fibrous granules are identical novel nonmembranous organelles containing PCM-1, which may play some important role(s) in centriolar replication. Expand
Dinoflagellate centrosome: Associated proteins old and new
TLDR
Cryofixation and cryofracture techniques enabled us to describe the ultrastructure of these centrosome regions which are devoid of classical centriolar structures. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 13 REFERENCES
Pathways of spindle assembly.
TLDR
Several molecules have been identified recently that are necessary for spindle assembly; these include proteins that regulate microtubule dynamics, proteins that organize microtubules minus ends into spindle poles, and members of the kinesin superfamily that reside on the chromosome arms. Expand
Centriole Disassembly In Vivo and Its Effect on Centrosome Structure and Function in Vertebrate Cells
TLDR
The results suggest that a posttranslational modification of tubulin is critical for long-term stability of centriolar microtubules and demonstrate that in animal cells, centrioles are instrumental in organizing centrosomal components into a structurally stable organelle. Expand
Basal body duplication in Paramecium requires γ-tubulin
TLDR
It is demonstrated that the inactivation of the Paramecium γ-tubulin genes leads to inhibition of basal body duplication, which is not tightly coupled to the nuclear division cycle. Expand
The core of the mammalian centriole contains γ-tubulin
TLDR
The localization of γ tubulin in isolated and in situ mammalian centrosomes is re-examined using a novel immunocytochemical technique that preserves antigenicity and morphology while allowing increased accessibility, suggesting a role in the centriolar duplication process. Expand
Microsurgical removal of centrosomes blocks cell reproduction and centriole generation in BSC-1 cells
TLDR
It is concluded that the removal of centrioles uncouples cell growth from cell reproduction and impedes centriole biogenesis and centrosome duplication. Expand
Loss of spatial control of the mitotic spindle apparatus in a Chlamydomonas reinhardtii mutant strain lacking basal bodies.
TLDR
It is proposed that the rootlet microtubules perform the functions of astral micro Tubules and that functional centrioles are necessary for the organization of the cytoskeletal superstructure critical for correct spindle and cleavage furrow placement in Chlamydomonas. Expand
The UNI3 gene is required for assembly of basal bodies of Chlamydomonas and encodes delta-tubulin, a new member of the tubulin superfamily.
TLDR
It is proposed that the Uni3 tubulin is involved in both the function and cell cycle-dependent maturation of basal bodies/centrioles in Chlamydomonas. Expand
Spindle Assembly and Mitosis without Centrosomes in Parthenogenetic Sciara Embryos
TLDR
Results indicate that the primary function of centrosomes is to provide astral microtubules for proper nuclear spacing and migration during the syncytial divisions of Sciara. Expand
Homology-dependent gene silencing in Paramecium.
TLDR
For the two multigene families that encode proteins that coassemble to build up complex subcellular structures the analysis presented herein provides the first experimental evidence that the members of these gene families are not functionally redundant. Expand
Randomization of Left–Right Asymmetry due to Loss of Nodal Cilia Generating Leftward Flow of Extraembryonic Fluid in Mice Lacking KIF3B Motor Protein
TLDR
The disrupted microtubule-dependent motor of murine KIF3B is essential for the left-right determination through intraciliary transportation of materials for ciliogenesis of motile primary cilia that could produce a gradient of putative morphogen along theleft-right axis in the node. Expand
...
1
2
...