Cell division: The renaissance of the centriole

  title={Cell division: The renaissance of the centriole},
  author={Wallace F. Marshall and Joel L. Rosenbaum},
  journal={Current Biology},

Cytoplasmic Dynein-mediated Assembly of Pericentrin and γ Tubulin onto Centrosomes

It is shown that in somatic cells centrosome assembly of two protea is disturbed and if defective may contribute to genomic instability in cancer.

Construction of Centrosomes and Spindle Poles by Molecular Motor‐Driven Assembly of Protein Particles

Recent evidence suggesting that assembly of centrosomes and mitotic spindle poles require transport of large protein particles along microtubules by the molecular motor cytoplasmic dynein is summarized.

Requirement of a Centrosomal Activity for Cell Cycle Progression Through G1 into S Phase

The observations reveal the existence of an activity associated with core centrosomal structures—distinct from elements of the microtubule-organizing center—that is required for the somatic cell cycle to progress through G1 into S phase, and that these core structures are not needed for the G2-M phase transition.

GFP‐centrin as a marker for centriole dynamics in living cells

The introduction of GFP‐centrin into cultured cells allows direct visualization of centriole behavior in living cells and in real time, and demonstrates that the biogenesis of new centrioles from individual members of a preexisting centRIole pair is asynchronous.

Centriole duplication and maturation in animal cells.

Mitotic kinase cascades orchestrating timely disjunction and movement of centrosomes maintain chromosomal stability and prevent cancer

Mechanisms that regulate centrosomes dynamics are reviewed, with emphasis on the roles of key mitotic kinases in the proper timing of centrosome dynamics and how aberrancies in these processes may cause chromosomal instability and cancer.

Distribution of tyrosinated and acetylated tubulin in centrioles during mitosis of 3T3 and SV40-3T3 cells

It was shown that the pattern of centriole immunostaining changed during the cell cycle in 3T3 (A31) cells, but not in tumorigenic SV40-3T3 cells.

Centriolar satellites: molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis.

It is suggested that 100riolar satellites and fibrous granules are identical novel nonmembranous organelles containing PCM-1, which may play some important role(s) in centriolar replication.

"It takes two to tango": understanding how centrosome duplication is regulated throughout the cell cycle.

The mechanisms that control centrosome duplication and coordinate it with nuclear events during the cell cycle are focused on.



Pathways of spindle assembly.

Centriole Disassembly In Vivo and Its Effect on Centrosome Structure and Function in Vertebrate Cells

The results suggest that a posttranslational modification of tubulin is critical for long-term stability of centriolar microtubules and demonstrate that in animal cells, centrioles are instrumental in organizing centrosomal components into a structurally stable organelle.

Loss of spatial control of the mitotic spindle apparatus in a Chlamydomonas reinhardtii mutant strain lacking basal bodies.

It is proposed that the rootlet microtubules perform the functions of astral micro Tubules and that functional centrioles are necessary for the organization of the cytoskeletal superstructure critical for correct spindle and cleavage furrow placement in Chlamydomonas.

The UNI3 gene is required for assembly of basal bodies of Chlamydomonas and encodes delta-tubulin, a new member of the tubulin superfamily.

It is proposed that the Uni3 tubulin is involved in both the function and cell cycle-dependent maturation of basal bodies/centrioles in Chlamydomonas.

Spindle Assembly and Mitosis without Centrosomes in Parthenogenetic Sciara Embryos

Results indicate that the primary function of centrosomes is to provide astral microtubules for proper nuclear spacing and migration during the syncytial divisions of Sciara.

Homology-dependent gene silencing in Paramecium.

For the two multigene families that encode proteins that coassemble to build up complex subcellular structures the analysis presented herein provides the first experimental evidence that the members of these gene families are not functionally redundant.