Cell-derived soluble oligomers of human amyloid-β peptides disturb cellular homeostasis and induce apoptosis in primary hippocampal neurons

@article{Yang2009CellderivedSO,
  title={Cell-derived soluble oligomers of human amyloid-β peptides disturb cellular homeostasis and induce apoptosis in primary hippocampal neurons},
  author={Ting-Ting Yang and Chao-Tien Hsu and Yu-Min Kuo},
  journal={Journal of Neural Transmission},
  year={2009},
  volume={116},
  pages={1561-1569}
}
The concentrations of soluble β-amyloid (Aβ) oligomers paralleled with the extent of synaptic loss and severity of cognitive impairment in Alzheimer patients. However, the neurotoxicity of the naturally generated Aβ species remains unknown. This study was designed to examine the effects of naturally generated Aβ oligomers, secreted from amyloid precursor… CONTINUE READING