Cell-derived microvesicles mediate the delivery of miR-29a/c to suppress angiogenesis in gastric carcinoma.

Abstract

Microvesicles (MVs) secreted from cells have been found to mediate signal transduction between cells. In the tumor microenvironment, VEGF released from cancer cells plays a key role in promoting tumor angiogenesis. In this study, we characterized the inhibitory effect of MV-delivered miR-29a/c on angiogenesis and tumor growth in gastric cancer (GC). We found that the downregulation of miR-29a/c increases VEGF expression and release in GC cells, promoting the growth of vascular cells. By simulating the tumor microenvironment, the MV-delivered miR-29a/c significantly suppresses VEGF expression in GC cells, inhibiting vascular cell growth, metastasis, and tube formation. We also used a tumor implantation mouse model to show that secreted MVs containing overexpressed miR-29a/c significantly reduced the growth rate of the vasculature and tumors in vivo. To conclude, our results contribute to a novel anti-cancer strategy using miRNA-containing MVs to control tumor cell growth by blocking angiogenesis.

DOI: 10.1016/j.canlet.2016.03.026
010020030020162017
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@article{Zhang2016CellderivedMM, title={Cell-derived microvesicles mediate the delivery of miR-29a/c to suppress angiogenesis in gastric carcinoma.}, author={Haiyang Zhang and Ming Bai and Ting Deng and Rui Liu and Xia Wang and Yanjun Qu and Jingjing Duan and Le Zhang and Tao Ning and Shaohua Ge and Hongli Li and Likun Zhou and Yuchen Liu and Dingzhi Huang and Guoguang Ying and Yi Ba}, journal={Cancer letters}, year={2016}, volume={375 2}, pages={331-339} }