Cell-derived matrix enhances osteogenic properties of hydroxyapatite.

  title={Cell-derived matrix enhances osteogenic properties of hydroxyapatite.},
  author={Gregory Tour and Mikael Wendel and Ion Tcacencu},
  journal={Tissue engineering. Part A},
  volume={17 1-2},
The study aimed to evaluate osteogenic properties of hydroxyapatite (HA) scaffold combined with extracellular matrix (ECM) derived in vitro from rat primary calvarial osteoblasts or dermal fibroblasts. The cellular viability, and the ECM deposited onto synthetic HA microparticles were assessed by MTT, Glycosaminoglycan, and Hydroxyproline assays as well as immunohistochemistry and scanning electron microscopy after 21 days of culture. The decellularized HA-ECM constructs were implanted in… CONTINUE READING


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