Cell density-dependent inhibition of epidermal growth factor receptor signaling by p38alpha mitogen-activated protein kinase via Sprouty2 downregulation.

@article{Swat2009CellDI,
  title={Cell density-dependent inhibition of epidermal growth factor receptor signaling by p38alpha mitogen-activated protein kinase via Sprouty2 downregulation.},
  author={Aneta Swat and Ignacio Dolado and Jos{\'e} Mar{\'i}a Rojas and Angel R Nebreda},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 12},
  pages={3332-43}
}
Contact inhibition is a fundamental process in multicellular organisms aimed at inhibiting proliferation at high cellular densities through poorly characterized intracellular signals, despite availability of growth factors. We have previously identified the protein kinase p38alpha as a novel regulator of contact inhibition, as p38alpha is activated upon cell-cell contacts and p38alpha-deficient cells are impaired in both confluence-induced proliferation arrest and p27(Kip1) accumulation. Here… CONTINUE READING

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