Cell density-dependent differential proliferation of neural stem cells on omnidirectional nanopore-arrayed surface

@inproceedings{Cha2017CellDD,
  title={Cell density-dependent differential proliferation of neural stem cells on omnidirectional nanopore-arrayed surface},
  author={Kyoung Je Cha and Sun-young Kong and Ji Soo Lee and Hyung Woo Kim and Jae-Yeon Shin and Moonwoo La and Byung Woo Han and Dong Sung Kim and Hyun-Jung Kim},
  booktitle={Scientific Reports},
  year={2017}
}
Recently, the importance of surface nanotopography in the determination of stem cell fate and behavior has been revealed. In the current study, we generated polystyrene cell-culture dishes with an omnidirectional nanopore arrayed surface (ONAS) (diameter: 200 nm, depth: 500 nm, center-to-center distance: 500 nm) and investigated the effects of nanotopography on rat neural stem cells (NSCs). NSCs cultured on ONAS proliferated better than those on the flat surface when cell density was low and… CONTINUE READING
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