Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma.

@article{Ekert2006CellDP,
  title={Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma.},
  author={Paul G Ekert and Anissa M. Jabbour and Anand Manoharan and Jacki E Heraud and Jai Y. Yu and Miha Pakusch and Ewa M Michalak and Priscilla Kelly and Bernard Andrew Callus and Thomas Kiefer and Anne M. Verhagen and John Silke and Andreas Strasser and Christoph Borner and David L. Vaux},
  journal={Blood},
  year={2006},
  volume={108 5},
  pages={1461-8}
}
Growth and survival of hematopoietic cells is regulated by growth factors and cytokines, such as interleukin 3 (IL-3). When cytokine is removed, cells dependent on IL-3 kill themselves by a mechanism that is inhibited by overexpression of Bcl-2 and is likely to be mediated by proapoptotic Bcl-2 family members. Bad and Bim are 2 such BH3-only Bcl-2 family members that have been implicated as key initiators in apoptosis following growth factor withdrawal, particularly in IL-3-dependent cells. To… CONTINUE READING

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Bad-deficient mice develop diffuse large B cell lymphoma.

Proceedings of the National Academy of Sciences of the United States of America • 2003

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