Cell death pathways in response to antitumor therapy.

@article{Portugal2009CellDP,
  title={Cell death pathways in response to antitumor therapy.},
  author={J. Portugal and M. Bataller and Sylvia Mansilla},
  journal={Tumori},
  year={2009},
  volume={95 4},
  pages={
          409-21
        }
}
Failure to eliminate cancer cells that have been exposed to cytotoxic agents may contribute to the development of resistance to antitumor drugs. A widespread model in present day oncology is that antitumor therapy involves the triggering of tumor cells to undergo apoptosis, and cells that can avoid apoptosis will be resistant to such therapy. Apoptosis is a defined program of cell death that is markedly influenced by the fact that many routes leading to it are mutated or deregulated in human… Expand
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