Cell death of melanophores in zebrafish trpm7 mutant embryos depends on melanin synthesis.

@article{McNeill2007CellDO,
  title={Cell death of melanophores in zebrafish trpm7 mutant embryos depends on melanin synthesis.},
  author={Matthew S. McNeill and Jennifer Paulsen and Gregory Bonde and Erin R. Burnight and Mei-Yu Hsu and Robert A Cornell},
  journal={The Journal of investigative dermatology},
  year={2007},
  volume={127 8},
  pages={
          2020-30
        }
}
Transient receptor potential melastatin 7 (TRPM7) is a broadly expressed, non-selective cation channel. Studies in cultured cells implicate TRPM7 in regulation of cell growth, spreading, and survival. However, zebrafish trpm7 homozygous mutants display death of melanophores and temporary paralysis, but no gross morphological defects during embryonic stages. This phenotype implies that melanophores are unusually sensitive to decreases in Trpm7 levels, a hypothesis we investigate here. We find… CONTINUE READING
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