Cell death mechanisms in eukaryotes

  title={Cell death mechanisms in eukaryotes},
  author={Jesuthankaraj Grace Nirmala and Manu Lopus},
  journal={Cell Biology and Toxicology},
Like the organism they constitute, the cells also die in different ways. The death can be predetermined, programmed, and cleanly executed, as in the case of apoptosis, or it can be traumatic, inflammatory, and sudden as many types of necrosis exemplify. Nevertheless, there are a number of cell deaths—some of them bearing a resemblance to apoptosis and/or necrosis, and many, distinct from each—that serve a multitude of roles in either supporting or disrupting the homoeostasis. Apoptosis is… 

Editorial: Non-apoptotic cell death mechanisms and their therapeutic significance

The ability of cancer cells to resist innately programmed or drug-induced apoptosis necessitates identification and targeting of non-apoptotic cell death for effective cancer treatment.

Signaling Role of NADPH Oxidases in ROS-Dependent Host Cell Death Induced by Pathogenic Entamoeba histolytica

Understanding of the mechanisms and signaling molecules involved in host cell death induced by amoeba can provide new insights on the tissue pathology and parasitism in human amoEBiasis.

Different types of cell death in vascular diseases.

By focusing on different pathways of cell death in different vascular diseases, an attempt is made to open a new perspective on the therapeutic goals associated with cell death as well as on responses of adjacent and infiltrating cells, which also have an effect on the pathology.

Autophagic Cell Death During Development – Ancient and Mysterious

  • L. Schwartz
  • Biology
    Frontiers in Cell and Developmental Biology
  • 2021
The goal of this mini-review is to summarize the field and to identify some of the major gaps in knowledge on autophagy, to facilitate the creation of better tools for both the diagnostics and treatment of disease.

Cell death as part of innate immunity: Cause or consequence?

This work provides an overview of the main cell death programmes and their implication in innate immunity not only as an immunogenic/inflammatory process, but also as an active defence strategy during immune response and at the same time as a regulatory mechanism.

The lysosome as an imperative regulator of autophagy and cell death

Lysosomal reformation, maintenance, and degradation pathways following the involvement of the lysosome in autophagy and cell death, which are related to several pathophysiological conditions observed in humans are discussed.

Natural Compounds of Marine Origin as Inducers of Immunogenic Cell Death (ICD): Potential Role for Cancer Interception and Therapy

Novel and repurposed small-molecule ICD triggers are discussed, particularly on marine microalgae derived molecules that are endowed with ICD-inducing properties and sulfavants, leading to immune stimulation, which could be used alone or in combinatorial immunotherapeutic strategies in cancer prevention and therapies.

Innate Immunity as an Executor of the Programmed Death of Individual Organisms for the Benefit of the Entire Population

It is argued that innate immunity may be involved in the implementation of an altruistic programmed death of an organism aimed at increasing the well-being of the whole community and combating this program should be a major goal of future medicine.

In Vitro Evaluation of the Apoptotic, Autophagic, and Necrotic Molecular Pathways of Fluoride.

It was concluded that these molecular mechanisms were activated with NaF, and different mechanisms accelerated the cellular death at the 24th hour, demonstrating NaF-induced cellular death in the NRK-52E cell line.

Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases

An overview of ferroptosis regulatory mechanisms, such as lipid metabolism, glutathione metabolism, and iron metabolism, are provided in this review.



Cell Death Signaling.

In multicellular organisms, cell death is a critical and active process that maintains tissue homeostasis and eliminates potentially harmful cells. There are three major types of morphologically

Molecular mechanisms of regulated necrosis.

Apoptosis: A Review of Programmed Cell Death

The goal of this review is to provide a general overview of current knowledge on the process of apoptosis including morphology, biochemistry, the role of apoptoses in health and disease, detection methods, as well as a discussion of potential alternative forms of apoptotic proteins.

Necrosis as Programmed Cell Death

This chapter presents a brief review of the apoptotic and autophagic cell death processes but focuses attention primarily on necrosis because it has previously been considered an accidental and uncontrolled form of cell death.

Apoptosis and Clearance of Apoptotic Cells.

  • S. Nagata
  • Biology
    Annual review of immunology
  • 2018
When apoptotic cells are not efficiently engulfed by macrophages, they undergo secondary necrosis and release intracellular materials that represent a damage-associated molecular pattern, which may lead to a systemic lupus-like autoimmune disease.

Necrosis: Molecular Mechanisms and Physiological Roles

This chapter focuses on the molecular events during regulated necrotic cell death and the link with several necrosis-associated pathologies.

Cell death and autophagy: cytokines, drugs, and nutritional factors.

Necroptotic Cell Death Signaling and Execution Pathway: Lessons from Knockout Mice

Recent discoveries into how the necrotic cell death execution pathway is engaged in many physiological and pathological outcome based on genetic analysis of knockout mice are outlined.

Crashing the computer: apoptosis vs. necroptosis in neuroinflammation

The effects of apoptotis and necroptosis on inflammatory immune activation, and the roles of each cell death pathway in a variety of pathologies with specific focus on neurodegeneration are discussed.