Cell death induction by the acute promyelocytic leukemia-specific PML/RARalpha fusion protein.

@article{Ferrucci1997CellDI,
  title={Cell death induction by the acute promyelocytic leukemia-specific PML/RARalpha fusion protein.},
  author={Pier Francesco Ferrucci and Francesco Grignani and Mark Pearson and Marta Fagioli and Ildo Nicoletti and Pier Giuseppe Pelicci},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 20},
  pages={
          10901-6
        }
}
PML/RARalpha is the abnormal protein product generated by the acute promyelocytic leukemia-specific t(15;17). Expression of PML/RARalpha in hematopoietic precursor cell lines induces block of differentiation and promotes survival. We report here that PML/RARalpha has a potent growth inhibitory effect on all nonhematopoietic cell lines and on the majority of the hematopoietic cell lines tested. Inducible expression of PML/RARalpha in fibroblasts demonstrated that the basis for the growth… CONTINUE READING

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Ferrucci et al

  • L. Benedetti, F. Grignani, +11 authors 1939–1950. 10906 Medical Sciences
  • Proc. Natl. Acad. Sci. USA 94
  • 1997
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