Cell death induction by isothiocyanates and their underlying molecular mechanisms.

@article{Nakamura2006CellDI,
  title={Cell death induction by isothiocyanates and their underlying molecular mechanisms.},
  author={Yoshimasa Nakamura and Noriyuki Miyoshi},
  journal={BioFactors},
  year={2006},
  volume={26 2},
  pages={123-34}
}
An important and promising group of compounds that have a chemopreventive property are organosulfur compounds, such as isothiocyanates (ITCs). In recent years, it has been shown that ITCs induce apoptosis in various cancer cell lines and experimental rodents. During the course of apoptosis induction by ITC, multiple signal-transduction pathways and apoptosis intermediates are modulated. We have also clarified the molecular mechanism underlying the relationship between cell cycle arrest and… CONTINUE READING
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