Cell death induced by the Fas/Fas ligand pathway and its role in pathology.

@article{Waring1999CellDI,
  title={Cell death induced by the Fas/Fas ligand pathway and its role in pathology.},
  author={Paul Waring and Arno M{\"u}llbacher},
  journal={Immunology and cell biology},
  year={1999},
  volume={77 4},
  pages={
          312-7
        }
}
Engagement of the cell death surface receptor Fas by Fas ligand (FasL) results in apoptotic cell death, mediated by caspase activation. Cell death mediated via Fas/FasL interaction is important for homeostasis of cells in the immune system and for maintaining immune-privileged sites in the body. Killing via the Fas/FasL pathway also constitutes an important pathway of killing for cytotoxic T cells. Fas ligand is induced in activated T cells, resulting in activation-induced cell death by the Fas… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 92 extracted citations

Similar Papers

Loading similar papers…