Cell death induced by granzyme C.

  title={Cell death induced by granzyme C.},
  author={Hillary Johnson and Luca Scorrano and S Stanley J. Korsmeyer and Timothy J. Ley},
  volume={101 8},
Although the functions of granzymes A and B have been defined, the functions of the other highly expressed granzymes (Gzms) of murine cytotoxic lymphocytes (C, D, and F) have not yet been evaluated. In this report, we describe the ability of murine GzmC (which is most closely related to human granzyme H) to cause cell death. The induction of death requires its protease activity and is characterized by the rapid externalization of phosphatidylserine, nuclear condensation and collapse, and single… CONTINUE READING
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