Cell death induced by Pteris semipinnata L. is associated with p53 and oxidant stress in gastric cancer cells.

Abstract

In this study, we demonstrated that Ent-11alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F) had stronger cytotoxicity against MKN-45, a gastric cancer cell line bearing wild-type p53 than MKN-28, another gastric cancer cell line containing missense mutation in p53. The rapid increase of ROS level was involved in the mechanism of cytotoxicity. Classical… (More)

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Cite this paper

@article{Liu2005CellDI, title={Cell death induced by Pteris semipinnata L. is associated with p53 and oxidant stress in gastric cancer cells.}, author={Zhimin Liu and Enders K. W. Ng and Nian-ci Liang and Yi-feng Deng and Billy C. S. Leung and George Guo-Qiang Chen}, journal={FEBS letters}, year={2005}, volume={579 6}, pages={1477-87} }